International Neuroblastoma Risk Group
Headquarters: University of Chicago
The INRG task force has established a database containing information on over 20,000 children with neuroblastoma from around the world. These data are available to investigators from around the world for data mining studies, and significant discoveries have already been made using this unique resource.
The patient data included in this database continues to expand. Cooperative groups have agreed to update existing patient data and add new patient data once clinical trials are completed and the objectives of the trial are published. The architecture housing the database has been transformed to a new web-based system with technology that enables linkage with other databases. This new Interactive International Neuroblastoma Risk Group database (iINRGdb) has been successfully linked to the Children’s Oncology Group (COG) Biopathology Center at The Research Institute at Nationwide Children’s Hospital that contains banked neuroblastoma tumor tissue from COG patients. The iINRGdb also contains data from the COG neuroblastoma nucleic acid bank. Thus, in addition to clinical information, investigators are now able to determine if banked tumor tissue or nucleic acids are available research studies on specific cohorts of patients. We anticipate that the iINRGdb will facilitate international, multi-institutional, interdisciplinary research in childhood neuroblastoma, advance our understanding of the pathogenesis of this neoplasm, and ultimately lead to the development of more effective treatment strategies for children with neuroblastoma.