Harnessing Collaborative Frameworks Across Consortia as Paired with Emerging National Data-driven Infrastructure to Advance Clinical Translation for Children with Brain Tumors

Conversations for the Common Good welcomes Adam Resnick, PhD, Director of the Center for Data Driven Discovery in Biomedicine at Children’s Hospital of Philadelphia and Principal Investigator of the Gabriella Miller Kids First Data Resource Center. Pediatric brain tumors are the leading cause of disease-related death in children. To address the unmet need for large-scale datasets that can inform new research and therapeutic development across the heterogeneous disease landscape of pediatric brain tumors, multi-institutional national/international consortia like the Children’s Brain Tumor Network have undertaken the centralized integration of samples and associated clinical/phenotypic patient data on behalf of a collaborative discovery research framework. Over the past five years, such efforts have further informed the development of the Gabriella Miller Kids First Data Resource, an NIH-supported, cloud-based platform focused on pediatric cross-disease analyses, as well as further contributed to NCI-sponsored data generation efforts supported by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and more recently the Childhood Cancer Data Initiative (CCDI). Together, these large-scale data and platform resources are newly poised to advance and inform an emerging pediatric data commons landscape on behalf of accelerated, collaborative discovery and translational clinical impact.

Presented on April 19, 2022.

Conversations for the Common Good is a guest speaker series hosted by D4CG. We’ve invited thought leaders from across the fields of oncology, clinical trials, and international data sharing to talk about big ideas that can redefine how we think about improving human health. The more we learn from each other, the better we can all work toward the common good.

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